Vacaay
1 / 4

Route 66

About Route 66

Route 66 is one of the most famous highways in the United States. Missouri is home to more than 280 miles of the "Mother Road," and features some of the Route's most historic tourist attractions. We recommend taking the "scenic route" and spending a couple of days to cover Missouri's section of Route 66.

When to visit

The best time to visit Route 66 in Missouri is during the autumn months, when the weather is pleasant and the fall colors are stunning.

Most popular: September - October

Spring · Mar, Apr, May

In spring, Route 66 in Missouri bursts into life. The landscape awakens with vibrant colors as wildflowers bloom along the roadside and in the surrounding fields. The weather is pleasantly mild, making it perfect for outdoor activities like hiking and biking along the scenic trails. Spring also marks the start of the tourist season, so travelers can expect a lively atmosphere in the small towns dotted along the route. Festivals and events begin to pop up, celebrating the rich history and culture of this iconic highway.

Summer · Jun, Jul, Aug

Summer on Route 66 in Missouri is all about sunny days and warm nights. This season is ideal for road trippers and adventure seekers. The numerous roadside attractions, from classic diners to quirky museums, are in full swing. Outdoor enthusiasts can enjoy camping and exploring the natural beauty of the Ozarks. The heat can be intense, but it's a great opportunity to indulge in some of the famous ice cream parlors and cool down in the refreshing waters of the Meramec River.

Autumn · Sep, Oct, Nov

Autumn transforms Route 66 into a picturesque canvas of red, orange, and yellow foliage. The cooler temperatures make it a perfect time for leisurely drives to admire the fall colors. Harvest festivals and pumpkin patches add to the charm of the small towns along the route. It's also a great time for antiquing and visiting local farmers' markets, where travelers can sample fresh, seasonal produce and regional specialties.

Winter · Dec, Jan, Feb

Winter on Route 66 in Missouri has a quiet, serene beauty. While some attractions may be closed, the snow-covered landscapes offer a peaceful and unique perspective of this historic route. It's a season for cozy diners and warm hospitality, with fewer tourists and more intimate experiences. Travelers can enjoy the holiday lights in towns along the route and partake in local holiday traditions, giving a glimpse into the heartland's winter charm.

Weather Highlights

  • Summer high

    31°C / 90°F

  • Winter low

    -2°C / 28°F

  • Rain

    110 days

  • Snow

    10 days

Location

Getting There

Route 66 is well marked, but there are many guide books and apps on the market that can provide you with turn by turn directions. The route stretches from St. Louis to Joplin, at many times following along Interstate 44.

You may also like

America the Beautiful — plan your trip with Booking.com
Advertisement
Advertisement

Book securely throughBooking.com

View Rates